Search results for "Security of supply"
showing 2 items of 2 documents
Assessing the effect of transmission constraints on wind power expansion in northeast Brazil
2019
Abstract The rapid growth of the wind industry in Brazil presents new opportunities and challenges for its electricity industry. As new capacity becomes available, more transmission infrastructure is required for security of supply. The Brazilian electricity system has experienced congestion in the northeast region, affecting the coordinated expansion of transmission and new wind power capacity. This paper uses a simulation model for better assessing long-term policy synchrony of the wind industry. The simulation shows that the resulting prices are competitive in the middle to long terms.
An Efficient Synthesis of Tenofovir (PMPA): A Key Intermediate Leading to Tenofovir-Based HIV Medicines
2020
Abstract: Herein, we report further improvements to the synthesis of tenofovir 1, the precursor to tenofovir disoproxil fumarate and tenofovir alafenamide fumarate. Starting from acyclic precursor diaminomalononitrile 12, a four-step protocol to tenofovir 1 will allow for vertical integration for more manufacturers. The key transformation is a more convergent one step procedure from 6 as compared to the current commercial process, with an improved yield from 59% (two steps) to 70%. Further improvements include eliminating the need for problematic magnesium tert-butoxide (MTB) and significant solvent reduction by eliminating the need for an intermediate workup. With the costs of HIV/AIDS tre…